IIHG Divisions

Bioinformatics

Clinical

Education

Genomics

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We are the people behind the scenes of the research projects that help keep the University of Iowa on the cutting edge of science. From cancer to cystic fibrosis to muscular dystrophy, we perform the lab tests and we do the analyses to help researchers achieve their ultimate goal of improving healthcare for you and your family. 

We also prepare today's undergraduates to be tomorrow's graduate students and your future researchers and healthcare providers. Over 50% of our summer interns successfully attend graduate school and pursue careers in STEM fields including Genetic Counseling, Medicine, Nursing, Computational Biology and Molecular Genetics. 

Genetics Cluster Initiative

Genetics transcends departments, colleges and disciplines and generates both needs and services in the basic sciences, health care, bioethics, law, bioinformatics and communications.

The Genetics Cluster Initiative at the University of Iowa includes professors from each of the aforementioned specialties, providing for a true round table discussion and collaborative approach to the unique nuances of personalized genomic medicine. 

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Ask a member of the Iowa Institute of Human Genetics your genetics-related question. Complete this online form and we will be happy to assist you

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Recent Publications

EHE cell cultures are a platform for mechanistic and therapeutic investigation

Friday, October 10, 2025
Nicholas Scalora
Epithelioid hemangioendothelioma (EHE) is a difficult to treat vascular sarcoma defined by TAZ-CAMTA1 (TC) or YAP-TFE3 (YT) fusion proteins. Human cell lines needed to further understand the pathogenesis of EHE have been lacking. Herein, we describe a method to generate EHE extended primary cell cultures. An integrated multi -omic and functional approach was used to characterize these cultures. The cell cultures, relatively homogenous by single cell RNA-Seq, demonstrated established...

Extracellular Vesicles-Induced Cell Homing and Odontogenesis via microRNA Signaling for Dentin Regeneration

Thursday, August 14, 2025
Venkateswaran Ganesh
Reparative tertiary dentinogenesis requires the recruitment and odontogenic differentiation of dental pulp stem cells (DPSCs). Extracellular vesicles (EVs) as bioactive molecules have gained attention in regenerative medicine for their ability to mediate tissue repair through intercellular communication, influencing cell recruitment, proliferation, and differentiation. This study aimed to evaluate the effects of EVs on DPSC homing and odontogenic differentiation for dentin regeneration....

Utility of Genetic Information for Management in Kidney Transplantation and Living Donation

Friday, July 18, 2025
Yasar Caliskan
Kidney transplantation is the best treatment for kidney failure in eligible patients, significantly improving survival and quality of life. While short-term post-transplant survival has improved, long-term outcomes remain limited. Advances in genetic research have the potential to transform kidney transplantation. The shortage of donor organs underscores the need for improved organ availability, optimized immunosuppression, and enhanced monitoring to minimize repeat transplants. Improved...

Maternal α-cypermethrin and permethrin exert differential effects on fetal growth, placental morphology, and fetal neurodevelopment in mice

Sunday, June 15, 2025
Benjamin A Elser
Pyrethroid insecticides represent a broad class of chemicals used widely in agriculture and household applications. Human studies show mixed effects of maternal pyrethroid exposure on fetal growth and neurodevelopment. Assessment of shared pyrethroid metabolites as a biomarker for exposure obscures effects of specific chemicals within this broader class. To better characterize pyrethroid effects on fetal development, we investigated maternal exposure to permethrin, a type I pyrethroid, and...

The impact of PCR duplication on RNAseq data generated using NovaSeq 6000, NovaSeq X, AVITI, and G4 sequencers

Wednesday, May 28, 2025
Natalia Zajac
CONCLUSIONS: Data generated with each of the four sequencing platforms presents similar associations between starting material amount and the number of PCR cycles on PCR duplicates, a similar number of detected genes, and comparable gene expression profiles.

Events

Apply for Innovation Challenge Pitch Competition Fall 2025

Thursday, November 6, 2025 (all day)
Virtual
Innovation Challenge is a university-wide competition with the goal to identify, advance and support the most innovative and entrepreneurial projects on campus.

Women In Micro & Immuno Coffee Hour

Monday, November 10, 2025 11:00am to 12:00pm
Carver Biomedical Research Building

Join us for the Women in Micro & Immuno Coffee Hour. It is the monthly coffee hour on the second Monday of the month from 11 a.m. to noon in 1289 CBRB. Enjoy coffee, pastries and contribute to the discussion!

This is open to ALL — students, staff, postdocs, and faculty interested in promoting women in science.

Speakers change monthly. Contact: jessica-tucker@uiowa.edu for details.

Department of Microbiology and Immunology Seminar Series

Monday, November 10, 2025 3:00pm to 4:00pm
Bowen Science Building

Seminar Series https://microbiology.medicine.uiowa.edu/about-us/seminars